Markov State Models Reveal a Two-Step Mechanism of miRNA Loading into the Human Argonaute Protein: Selective Binding followed by Structural Re-arrangement
Fig 2
Projection of hAgo2-miRNA docking models built from the selected structures of open microstates.
Red dots mark the successful docking models and black dots mark the unsuccessful ones. A successful docking model is a hAgo2-miRNA docking pose where at least two native contacts are preserved at each miRNA terminus.