Bilinearity in Spatiotemporal Integration of Synaptic Inputs
Figure 6
Dendritic integration of a pair of excitatory inputs.
(A–D) Simulation results with two excitatory inputs given at the location and
. (A) The SC amplitude is plotted against the product of the two EPSP amplitudes, at the time
when one of the EPSPs reaches its peak (Note that
is plotted). Varying
and
less than
, it can be seen that
increases linearly with
. (B) Dendritic integration in the time interval
, where
. (upper)
for the goodness of the linear fitting of
vs.
at different times. (lower) The shunting coefficient
(in the unit of
) as the slope of the linear fitting is plotted at different times. The error bar indicates
confidence interval (The error bars are relatively small and are within the circles). The circle marked by red indicates the case in (A). (C–D) The same as (A–B) except that one of the EPSPs is elicited
earlier than the other. (E–F) Our experimental result shows the nearly linear summation for (E) a pair of concurrent excitatory inputs and (F) nonconcurrent excitatory inputs with arrival time difference
, when two excitatory inputs are given at the location
and at
.