Bilinearity in Spatiotemporal Integration of Synaptic Inputs
Figure 4
Dendritic integration of a pair of excitatory and inhibitory inputs.
(A–D) Simulation results with the excitatory input given at the location and the inhibitory input given at the location
. (A) The SC amplitude is plotted against the product of EPSP amplitude and IPSP amplitude, at the time when EPSP reaches its peak, i.e.,
(Note that
and
are plotted). Varying
less than
and varying
less than
, it can be seen that
increases linearly with
. (B) Dendritic integration in the time interval
, where
. (upper)
for the goodness of the linear fitting of
vs.
at different times. (lower) The shunting coefficient
(in the unit of
) as the slope of the linear fitting is plotted at different times. The error bar indicates
confidence interval (The error bars are relatively small and are within the circles). The circle marked by red indicates the case in (A). (C–D) The same as (A–B) except that the IPSP is elicited
before the EPSP. (E–H) Experimental results with the excitatory input given at the location
and the inhibitory input given at the location
. (E–F) for concurrent inputs and (G–H) for nonconcurrent inputs that the IPSP is elicited
earlier than the EPSP.