A New Model for Pore Formation by Cholesterol-Dependent Cytolysins
Figure 2
Identification of rigid fragments in CDC structures.
A & B. Structural alignment of all CDC structures and corresponding Lesk-Hubbard plot. 3.7 Å Cα-RMSD for 429 conserved positions; the common core at 1.3 Å sieving RMSD (indicated by the arrow) in B in red (228 positions). In Domain 3, the β5 strand and the TMH2 helical bundle are regions of plastic deformation. C & D. Structural alignment of all CDC Domain 2 and 4 structures and corresponding Lesk-Hubbard plot. 1.9 Å Cα-RMSD for 157 residues; common core at 0.8 Å sieving RMSD (indicated by the arrow) in red (78 positions). The undecapeptide and the protruding β-hairpin are regions of plasticity.