Pierced Lasso Bundles Are a New Class of Knot-like Motifs
Figure 6
Crystal structure of the leptin receptor complex.
The figure shows the leptin receptor complex (PDB code 1AX8 and 3V6O, [40]). The structure of leptin is color-coded according to changes in NSDs, where increased dynamics in the oxidized state is shown in red and increased dynamics in the reduced state is shown in blue. It is clear that there are more dynamics in the oxidized state versus the reduced state. Interestingly, the largest changes in the oxidized state occur at the receptor interface. Previously published results from in vitro activity assays in human cell lines showed that oxidized leptin is more active than reduced leptin [12]. This suggests that leptin benefits from being malleable for receptor interaction.