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Interplay of Intrinsic and Synaptic Conductances in the Generation of High-Frequency Oscillations in Interneuronal Networks with Irregular Spiking
Figure 11
Neuronal dynamics if inhibition is shunting, rather than hyperpolarizing.
A: Resting potential as a function of the background inhibition-to-excitation ratio k for the canonical value of 
(solid lines), and as a function of the background synaptic excitation 
for the canonical value of 
(dashed lines). Solid lines refer to the bottom axis; dashed lines to the top axis. Circles show the canonical values of the corresponding parameters. All parameters as in Table 1, except 
= 4 mV. Compare with analogous results for hyperpolarizing inhibition shown in Figure 1A. B: Synchrony (as assessed by 
) as a function of the background inhibition-to-excitation ratio 
for different values of the coupling strength 
. Voltage threshold for spike generation 
has been increased to 15 mV in the canonical models, in order to compensate for the depolarization of the resting potential and to keep the models in the fluctuation-driven regime. Voltage thresholds for r-matched models have been scaled accordingly for each value of 
. GIF: purple, weak coupling (
); blue, medium coupling (
); light blue, strong coupling (
). IF: brown, weak coupling; red, medium coupling; orange, strong coupling. All other parameters as in Table 1, except 
= 4 mV, 
= 4 mV. Dots indicate simulated points, lines are drawn to guide the eye.
doi: https://doi.org/10.1371/journal.pcbi.1003574.g011