Chemical, Target, and Bioactive Properties of Allosteric Modulation
Figure 3
L2 target class distribution of both the allosteric (A) and non-allosteric data (B) sets.
The distribution of the target classes differed between the two sets; which confirmed that targets that are easy to hit via non-allosteric inhibitors are not necessarily easy to hit via an allosteric modulator and vice versa. Abbreviations: 7TM1 - Class A GPCRs, 7TM2 - Class B GPCRs, 7TM3 - Class C GPCRs, IP3 - Inositol triphosphate receptors, KIR - Killer-cell Immunoglobulin-like Receptors, LGIC - Ligand Gated Ion Channels, RYR - Ryanodine Receptors, SUR - Sulfonylurea Receptors, TRP - Transient receptor potential channels, VGC - Voltage Gated Ion Channels.