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Bidirectional Control of Absence Seizures by the Basal Ganglia: A Computational Evidence
Figure 7
An example illustrating that the bidirectional control of absence seizures by the basal ganglia is also available for the corticothalamic loop transmission delay induced SWDs.
A, B: Tow-dimensional state analysis (A) and corresponding frequency analysis (B) in the (
) panel. Here 
is the scale factor, and 
represents the excitatory coupling strength of the STN-SNr pathway. Four different dynamical states are observed in (A): the saturation state (I), the SWD oscillation state (II), the simple oscillation state (III) and the low firing state (IV), which also correspond to previous figures. In (A), the region between two red dashed lines denotes the main bidirectional suppression region of SWDs, where the double arrow represents both increasing and decreasing the excitatory coupling strength 
can inhibit the SWDs. In (B), the yellow asterisk region surrounded by black dashed lines denotes the typical 2–4 Hz SWD oscillation region. (C) Three typical time series of 
for different values of 
, with 
. Here we choose 
(top), 
(middle) and 
(bottom), respectively. In all simulations, we set 
, 
, 
, 
, 
and 
.
doi: https://doi.org/10.1371/journal.pcbi.1003495.g007