A Simple Rule for Dendritic Spine and Axonal Bouton Formation Can Account for Cortical Reorganization after Focal Retinal Lesions
Figure 5
Differences in electrical activity in the LPZ and peri-LPZ account for network repair.
For growth rules with low and high
(here
and
), cooperative effects emerge between the peri-LPZ and LPZ that lead to a significant increase in activity in the center and the border of the LPZ. During the early phase (A), activities and calcium concentrations in the LPZ are higher than
but lower than
, leading to dendritic element formation and reduction of axonal elements. In the middle phase (B), activities in the border region of the LPZ now exceed
and cells in the border form axonal elements, too. In the late phase (C), all activities have returned close to the set-point
. Growth curves for axonal elements are drawn in red and for dendritic elements in black. The cyan spot on the x-axis indicates the set-point
. The colored bars schematically indicate the range of calcium concentration in the peri-LPZ (green), the border of the LPZ (orange), and the center of the LPZ (blue). Colored bars have transparent fillings to show overlaps.