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Detecting and Removing Inconsistencies between Experimental Data and Signaling Network Topologies Using Integer Linear Programming on Interaction Graphs

Figure 4

Interaction graph model of the EGFR/ErbB signaling network.

(A) The full network adopted from [18] after removal of non-observable and non-controllable nodes. All edges are activating edges (having positive signs). (B) The compressed model obtained after applying the compression rules to (A).

Figure 4

doi: https://doi.org/10.1371/journal.pcbi.1003204.g004