Probing the Energy Landscape of Activation Gating of the Bacterial Potassium Channel KcsA
Figure 2
Pore radius profiles derived from backbone atoms of channel states.
A) 3D representation of the pore domain depicting the HOLE profile. For the sake of clarity, only two opposing SUs are shown. B) Comparison of the profiles formed by the closed (red dashed line), intermediate (blue dashed line), and open (green dashed line) crystal structures with the average of the ten ED simulation structures (black dashed line). The subtle differences of the ED simulation structures in the activation gate region are indicated as standard deviation by error bars.