Synthetic Lethality between Gene Defects Affecting a Single Non-essential Molecular Pathway with Reversible Steps
Figure 5
Visualization of the steady states for the toy model in dependence of various parameters.
The phase diagrams (r2×r1 plane) show the qualitative behavior for small, intermediate and large values of the model parameters. Red color corresponds to the state for which Ps>0.5 (DNA is repaired with probability >50%). If Ps<0.5 then the color is chosen as green if the probability of trapping in the intermediate state (I) is bigger than the propability of the initial unrepaired state (S), and as blue in the opposite case. The case k1 = 0 (F1↓) is represented separately on the right. In this case, another parameter is used instead of r1 for the phase plane. The case k−1 = 0 (R1↓) is treated separately on the top and only the r2 value is varied. The 14 model simulations listed in Figure 6 are shown by the circled numbers in the position of the chosen parameters.