Connecting a Connectome to Behavior: An Ensemble of Neuroanatomical Models of C. elegans Klinotaxis
Figure 8
Range of sensitivity to changes in concentration.
A, Interneuron class AIY. B, Interneuron class AIZ. Left neuron shown in blue; right neurons shown in red. Flat regions of the curve correspond to areas of no-sensitivity to input over that region. The slope of the curve denotes the degree of sensitivity to changes around that region of the input. For example, AIYR is sensitive to large positive changes in concentration only, whereas AIYL is sensitive to changes in concentration around the midline. Dashed lines show the sensitivity when the gap junction between those two neurons is blocked. In AIY, blocking the gap junction does not affect the sensitivity of its left and right neurons. In AIZ, blocking the gap junction results in substantial differences in the range of sensitivity. C, D, Sensitivity in the left and right pair of motor neurons as a function of the phase of locomotion, respectively. The dorsal motor neuron is shown in blue-green-yellow shades; the ventral motor neuron is shown in gray scale. Similar to the interneurons, the motor neurons have a selective range of sensory input over which they are sensitive. Unlike the interneurons, their sensitivity changes as a function of the worm's sinusoidal movement. Because of the out of phase oscillation between dorsal and ventral motor neurons, which neuron is more sensitive to a certain input swaps back and forth between them.