Confidence-based Somatic Mutation Evaluation and Prioritization
Figure 3
Process of selection of mutations for validation.
A The Venn diagram shows the numbers of somatic variations in protein coding exons, found by the individual, two or all three software tools, respectively. The numbers were calculated after the recommended filtering procedures (see Methods section) and represent the consensus of all three samples. B List of unfiltered somatic mutations found in the consensus of all three samples, sorted by FDR (low to high from top to bottom). Each row represents a predicted mutation and it is indicated which program did the prediction. C For each mutation a FDR can be calculated, which is used for prioritization of the validation experiment.