Modeling Mechanisms of In Vivo Variability in Methotrexate Accumulation and Folate Pathway Inhibition in Acute Lymphoblastic Leukemia Cells
Figure 6
Individual simulated intracellular MTXPG and intracellular folate concentrations vs time.
Dose: 1 g/m2; Infusion time: 24 hrs. Red: DHF; Green: THF; Light Blue: 5,10-CH2-THF; Magenta: 5mTHF; Yellow: 5,10-CH = THF; Dark Blue: 10f-THF; Solid Black: MTXPG1; Dashed Black: MTXPG2-7.