The Role of Oligomerization and Cooperative Regulation in Protein Function: The Case of Tryptophan Synthase
Figure 5
H–bond network in the dimeric and monomeric complexes.
Quantitative comparison of the H–bond network for the dimeric and monomeric complexes of the ligand–bound–reference (LBR) state for residues located at the interface and residues interacting with ligands in the active sites. (a) α–subunit in the α/β–dimeric unit versus α–monomeric unit, (b) β–subunit in the α/β–dimeric unit versus β–monomeric unit. IGP and A-A are the α– and β–site ligands and represent 3-indole-D-glycerol-3′-phosphate and aminoacrylate, respectively. The x–axis is labeled with the interacting pair of residues, with the ligands blue and the protein residues in black.