Modeling Signal Propagation Mechanisms and Ligand-Based Conformational Dynamics of the Hsp90 Molecular Chaperone Full-Length Dimer
Figure 13
Structural analysis of the communicating residues in the Hsp90 dimer.
Residues active in long range signalling (i.e. active in communication with other residues that are more than 40 Angstroms apart) are coloured according to the following scheme: yellow: Residues active both in ATP and ADP system. Red: Residues active in the ATP system. Blue: Residues active in the ADP system. Mutation sites leading to different phenotypes [49] are highlighted with spheres and labelled.