Computational and Experimental Analysis of Redundancy in the Central Metabolism of Geobacter sulfurreducens
Figure 3
Optimal Equivalent Reactions Sets Studied
The sets were identified in the metabolism of G. sulfurreducens using the FVA analysis during acetate oxidation with either fumarate or Fe(III) citrate as the acceptor, (A) pyruvate to acetyl-CoA and (B) succinyl-CoA to succinate; and non-optimal central metabolism alternate pathways studied, (C) the redundant pathways for conversion of malate to oxaloacetate and (D) the pathways for synthesis of phosphoenolpyruvate (PEP) from pyruvate. The energetically favorable pathways selected in the model simulations are enclosed in the red box.
Ack, Acetate kinase; Adk1, Adenylate kinase; Ato, Acetyl CoA transferase; Fdh, Formate dehydrogenase; Me, Malic enzyme; Mdh, Malate dehydrogenase; Pc, Pyruvate carboxylase; Pdh, Pyruvate dehydrogenase; Pfl, Pyruvate formate lyase; Por, Pyruvate oxidoreductase; Ppa, diphosphatase; Ppck, Phosphoenolpyruvate carboxykinase; Ppdk, pyruvate phosphate dikinase; Ppsa, PEP synthase; Pta, Phosphotransacetylase; Sucoas, Succinyl-CoA synthetase.