In Silico Detection of Sequence Variations Modifying Transcriptional Regulation
Figure 4
Distributions of Mean phastCons Scores for SNPs located at Different Distances from the TSS
SNPs were given the mean phastCons scores from multiple alignments of human, chimp, mouse, rat, dog, chicken, fugu, and zebrafish in windows of 21 bp centered at the SNPs. For every interval a student's T-test was performed to check if there were significant differences in the distributions of phastCons values for the regulatory and background SNPs; the p-values from these tests are indicated above each pair of boxes.