Comparative Genomics Search for Losses of Long-Established Genes on the Human Lineage
Figure 4
Timing of Gene Birth Is Estimated by Determining Duplication Histories of Genomic Regions Surrounding the Gene Losses
For the subset of gene losses with detectable human self-alignment, the duplication branch is determined by tracing each duplicate of the best human self-alignment through a seven-species syntenic genomic alignment. For those without detectable self-alignments, the duplication branch is determined by the seven-species syntenic alignments plus alignments with the chicken genome, and the elephant, tenrec, and armadillo scaffolds when available. Filled rectangles represent syntenic alignment to the human genome, and open rectangles represent genomes or scaffolds aligned to the human genome without the syntenic constraint. Approximate time when the species diverged from the human lineage is shown in Mya.