Empirical Multiscale Networks of Cellular Regulation
Figure 5
Contribution of Smaller-Scale Modules to Larger-Scale Modules and Aggregation of Ontological Function
(A–C) Mappings of modules at finer scales (right array) to larger scales (left array). Size of a wedge of a particular color indicates the fraction of genes in that module that were placed in the larger-scale module of matching color. All arrays are in the SOM order.
(D) Colored outer circles indicate representative GO category labels that are statistically overrepresented in modules at n = 12 and 20. Inner circles are the same as (A).
(E) Individual GO labels within the GO category transcription regulation clustered by similarity of their enrichment fraction across the n = 12 and 20 SOM modules. Gray and blue indicate under- and overrepresentation, respectively. See scale.
(F) Similar to (E) for the GO category lipid processing.
(G) GO labels appearing 10 or more times clustered by distribution across the n = 12 and 20 modules. Doubly outlined boxes indicate clades with closely related function. Singly outlined boxes are within four branches of functionally related ontologies, indicated by the arcs.