Both Ligand- and Cell-Specific Parameters Control Ligand Agonism in a Kinetic Model of G Protein–Coupled Receptor Signaling

doi:10.1371/journal.pcbi.0030006

Both Ligand- and Cell-Specific Parameters Control Ligand Agonism in a Kinetic Model of G Protein–Coupled Receptor Signaling

Figure 3

Example of the Time Course of PRCC Values

Time course of PRCC values for LR association rate constant (k₃) and LR equilibrium association constant (K_a) correlated to %OverBasal (as given by Equation 1) when [L] = 1 nM.

doi: https://doi.org/10.1371/journal.pcbi.0030006.g003