Molecular Simulations of Cotranslational Protein Folding: Fragment Stabilities, Folding Cooperativity, and Trapping in the Ribosome
Figure 5
Effect of Confinement on Folding of CI2 and Barnase
(A) Mean values of Q during coupled synthesis–folding of CI2 in the presence (filled circles) and absence (open circles) of the ribosome.
(B) Same as (A), but for barnase.
(C) Mean values of the residue-specific Qres value during coupled synthesis–folding of CI2 in the presence of the ribosome; separate lines are plotted for each residue, colored from blue to red. Arrows indicate periods in which several of the Qres values suddenly decrease in concert.
(D) Same as (C), but for barnase; note that for clarity, only the period of synthesis of the first 60 residues is shown.