Mapping genes for human face shape: Exploration of univariate phenotyping strategies

• Meng Yuan ,

  Contributed equally to this work with: Meng Yuan, Seppe Goovaerts

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: meng.yuan@kuleuven.be (MY); seppe.goovaerts@kuleuven.be (SG); peter.claes@kuleuven.be (PC)

  Affiliations Department of Electrical Engineering, ESAT/PSI, KU Leuven, Leuven, Belgium, Department of Human Genetics, KU Leuven, Leuven, Belgium, Medical Imaging Research Center, University Hospitals Leuven, Leuven, Belgium

  https://orcid.org/0000-0003-0922-8012

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• Seppe Goovaerts ,

  Contributed equally to this work with: Meng Yuan, Seppe Goovaerts

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Writing – review & editing

  * E-mail: meng.yuan@kuleuven.be (MY); seppe.goovaerts@kuleuven.be (SG); peter.claes@kuleuven.be (PC)

  Affiliations Department of Human Genetics, KU Leuven, Leuven, Belgium, Medical Imaging Research Center, University Hospitals Leuven, Leuven, Belgium

  https://orcid.org/0000-0001-5176-8552

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• Michiel Vanneste,

  Roles Data curation, Resources, Writing – review & editing

  Affiliations Department of Human Genetics, KU Leuven, Leuven, Belgium, Medical Imaging Research Center, University Hospitals Leuven, Leuven, Belgium

  https://orcid.org/0000-0003-0222-5740

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• Harold Matthews,

  Roles Data curation, Resources, Software, Writing – review & editing

  Affiliations Department of Human Genetics, KU Leuven, Leuven, Belgium, Medical Imaging Research Center, University Hospitals Leuven, Leuven, Belgium, Murdoch Children’s Research Institute, Melbourne, Victoria, Australia

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• Hanne Hoskens,

  Roles Data curation, Resources, Writing – review & editing

  Affiliations Department of Electrical Engineering, ESAT/PSI, KU Leuven, Leuven, Belgium, Department of Human Genetics, KU Leuven, Leuven, Belgium, Medical Imaging Research Center, University Hospitals Leuven, Leuven, Belgium, Department of Cell Biology & Anatomy, Cumming School of Medicine, Alberta Children’s Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada

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• Stephen Richmond,

  Roles Data curation, Resources, Writing – review & editing

  Affiliation Applied Clinical Research and Public Health, School of Dentistry, Cardiff University, Cardiff, United Kingdom

  https://orcid.org/0000-0001-5449-5318

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• Ophir D. Klein,

  Roles Data curation, Funding acquisition, Resources, Writing – review & editing

  Affiliations Departments of Orofacial Sciences and Pediatrics, and Institute for Human Genetics, University of California, San Francisco, San Francisco, California, United States of America, Department of Pediatrics, Cedars-Sinai Guerin Children’s, Los Angeles, California, United States of America

  https://orcid.org/0000-0002-6254-7082

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• Richard A. Spritz,

  Roles Data curation, Funding acquisition, Resources, Writing – review & editing

  Affiliation Human Medical Genetics and Genomics Program, University of Colorado School of Medicine, Aurora, Colorado, United States of America

  https://orcid.org/0000-0002-8325-0026

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• Benedikt Hallgrimsson,

  Roles Data curation, Funding acquisition, Resources, Writing – review & editing

  Affiliation Department of Cell Biology & Anatomy, Cumming School of Medicine, Alberta Children’s Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada

  https://orcid.org/0000-0002-7192-9103

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• Susan Walsh,

  Roles Data curation, Resources, Writing – review & editing

  Affiliation Department of Biology, Indiana University Indianapolis, Indianapolis, Indiana, United States of America

  https://orcid.org/0000-0002-7064-1589

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• Mark D. Shriver,

  Roles Data curation, Resources, Writing – review & editing

  Affiliation Department of Anthropology, Pennsylvania State University, State College, Pennsylvania, United States of America

  https://orcid.org/0000-0003-0006-0479

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• John R. Shaffer,

  Roles Data curation, Funding acquisition, Resources, Writing – review & editing

  Affiliations Center for Craniofacial and Dental Genetics, Department of Oral and Craniofacial Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  https://orcid.org/0000-0003-1897-1131

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• Seth M. Weinberg,

  Roles Data curation, Funding acquisition, Resources, Writing – review & editing

  Affiliations Center for Craniofacial and Dental Genetics, Department of Oral and Craniofacial Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Anthropology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  https://orcid.org/0000-0001-9467-4556

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• Hilde Peeters,

  Roles Data curation, Resources, Supervision, Writing – review & editing

  Affiliation Department of Human Genetics, KU Leuven, Leuven, Belgium

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• Peter Claes

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: meng.yuan@kuleuven.be (MY); seppe.goovaerts@kuleuven.be (SG); peter.claes@kuleuven.be (PC)

  Affiliations Department of Electrical Engineering, ESAT/PSI, KU Leuven, Leuven, Belgium, Department of Human Genetics, KU Leuven, Leuven, Belgium, Medical Imaging Research Center, University Hospitals Leuven, Leuven, Belgium, Murdoch Children’s Research Institute, Melbourne, Victoria, Australia

  https://orcid.org/0000-0001-9489-9819

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