From cells to tissue: How cell scale heterogeneity impacts glioblastoma growth and treatment response

• Jill A. Gallaher ,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: jill.gallaher@moffitt.org (JAG); alexander.anderson@moffitt.org (ARAA)

  Affiliation Integrated Mathematical Oncology, Moffitt Cancer Center, Tampa, Florida, United States of America

  http://orcid.org/0000-0001-9831-6676

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• Susan C. Massey ,

  Contributed equally to this work with: Susan C. Massey, Andrea Hawkins-Daarud

  Roles Conceptualization, Investigation, Writing – original draft, Writing – review & editing

  Affiliations Precision NeuroTherapeutics Innovation Program, Mathematical NeuroOncology Lab, Mayo Clinic, Phoenix, Arizona, United States of America, Department of Neurological Surgery, Mayo Clinic, Phoenix, Arizona, United States of America

  http://orcid.org/0000-0002-4680-7796

  ⨯
• Andrea Hawkins-Daarud ,

  Contributed equally to this work with: Susan C. Massey, Andrea Hawkins-Daarud

  Roles Conceptualization, Investigation, Writing – original draft, Writing – review & editing

  Affiliations Precision NeuroTherapeutics Innovation Program, Mathematical NeuroOncology Lab, Mayo Clinic, Phoenix, Arizona, United States of America, Department of Neurological Surgery, Mayo Clinic, Phoenix, Arizona, United States of America

  http://orcid.org/0000-0002-6391-4155

  ⨯
• Sonal S. Noticewala,

  Roles Data curation, Formal analysis

  Affiliations Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York, United States of America, Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

  http://orcid.org/0000-0003-1894-7959

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• Russell C. Rockne,

  Roles Investigation, Validation, Writing – review & editing

  Affiliation Division of Mathematical Oncology, City of Hope National Medical Center, Duarte, California, United States of America

  http://orcid.org/0000-0002-1557-159X

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• Sandra K. Johnston,

  Roles Data curation

  Affiliations Precision NeuroTherapeutics Innovation Program, Mathematical NeuroOncology Lab, Mayo Clinic, Phoenix, Arizona, United States of America, Department of Neurological Surgery, Mayo Clinic, Phoenix, Arizona, United States of America, Department of Radiology, University of Washington, Seattle, Washington, United States of America

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• Luis Gonzalez-Cuyar,

  Roles Data curation

  Affiliation Department of Pathology, University of Washington, Seattle, Washington, United States of America

  http://orcid.org/0000-0002-8424-8331

  ⨯
• Joseph Juliano,

  Roles Investigation, Writing – review & editing

  Affiliation Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

  http://orcid.org/0000-0003-2527-0667

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• Orlando Gil,

  Roles Data curation, Formal analysis

  Affiliations Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York, United States of America, Department of Biology, Hunter College, City University of New York, New York, New York, United States of America

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• Kristin R. Swanson ,

  Roles Conceptualization, Funding acquisition, Project administration, Writing – review & editing

  ¶‡ KRS, PC, ARAA also contributed equally to this work

  Affiliations Precision NeuroTherapeutics Innovation Program, Mathematical NeuroOncology Lab, Mayo Clinic, Phoenix, Arizona, United States of America, Department of Neurological Surgery, Mayo Clinic, Phoenix, Arizona, United States of America

  http://orcid.org/0000-0002-2464-6119

  ⨯
• Peter Canoll ,

  Roles Data curation, Funding acquisition, Investigation, Writing – review & editing

  ¶‡ KRS, PC, ARAA also contributed equally to this work

  Affiliation Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York, United States of America

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• Alexander R. A. Anderson

  Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: jill.gallaher@moffitt.org (JAG); alexander.anderson@moffitt.org (ARAA)

  ¶‡ KRS, PC, ARAA also contributed equally to this work

  Affiliation Integrated Mathematical Oncology, Moffitt Cancer Center, Tampa, Florida, United States of America

  http://orcid.org/0000-0002-2536-4383

  ⨯