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Open Access
Peer-reviewed
Research Article
Model-based analysis of influenza A virus replication in genetically engineered cell lines elucidates the impact of host cell factors on key kinetic parameters of virus growth
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Tanja Laske ,
Contributed equally to this work with: Tanja Laske, Mandy Bachmann
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing
* E-mail: laske@mpi-magdeburg.mpg.de
Affiliation Department of Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany
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Mandy Bachmann ,
Contributed equally to this work with: Tanja Laske, Mandy Bachmann
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing
Current address: Genome Engineering Facility, Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany
Affiliation Department of Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany
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Melanie Dostert,
Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing
Current address: Center for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, Canada
Affiliation Department of Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany
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Alexander Karlas,
Roles Conceptualization, Funding acquisition, Resources, Writing – review & editing
Current address: Viral Vaccines Development, ProBioGen AG, Berlin, Germany
Affiliation Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany
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Dagmar Wirth,
Roles Conceptualization, Funding acquisition, Investigation, Methodology, Resources, Validation, Writing – review & editing
Affiliations Research Group Model Systems for Infection and Immunity, Helmholtz Center for Infection Research, Braunschweig, Germany, Division of Experimental Hematology, Medical University Hannover, Hannover, Germany
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Timo Frensing,
Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing
Current address: Pharma Research and Early Development, Roche Diagnostics GmbH, Penzberg, Germany
Affiliation Department of Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany
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Thomas F. Meyer,
Roles Conceptualization, Funding acquisition, Resources, Writing – review & editing
Affiliation Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany
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Hansjörg Hauser,
Roles Conceptualization, Funding acquisition, Resources, Writing – review & editing
Affiliation Department of Gene Regulation and Differentiation, Helmholtz Center for Infection Research, Braunschweig, Germany
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Udo Reichl
Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing
Affiliations Department of Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany, Chair of Bioprocess Engineering, Faculty of Process and Systems Engineering, Otto von Guericke University, Magdeburg, Germany
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Model-based analysis of influenza A virus replication in genetically engineered cell lines elucidates the impact of host cell factors on key kinetic parameters of virus growth
- Tanja Laske,
- Mandy Bachmann,
- Melanie Dostert,
- Alexander Karlas,
- Dagmar Wirth,
- Timo Frensing,
- Thomas F. Meyer,
- Hansjörg Hauser,
- Udo Reichl
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- Published: April 11, 2019
- https://doi.org/10.1371/journal.pcbi.1006944