PathFX provides mechanistic insights into drug efficacy and safety for regulatory review and therapeutic development

• Jennifer L. Wilson,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Bioengineering, Stanford University, Palo Alto California, United States of America

  http://orcid.org/0000-0002-2328-2018

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• Rebecca Racz,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation Division of Applied Regulatory Science, US Food and Drug Administration, Silver Spring Maryland, United States of America

  http://orcid.org/0000-0002-5487-5692

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• Tianyun Liu,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation Department of Bioengineering, Stanford University, Palo Alto California, United States of America

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• Oluseyi Adeniyi,

  Roles Conceptualization, Writing – review & editing

  Affiliation Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring Maryland, United States of America

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• Jielin Sun,

  Roles Conceptualization, Writing – review & editing

  Affiliation Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring Maryland, United States of America

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• Anuradha Ramamoorthy,

  Roles Conceptualization, Writing – review & editing

  Affiliation Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring Maryland, United States of America

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• Michael Pacanowski,

  Roles Conceptualization, Writing – review & editing

  Affiliation Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring Maryland, United States of America

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• Russ Altman

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Writing – review & editing

  * E-mail: rbaltman@stanford.edu

  Affiliations Department of Bioengineering, Stanford University, Palo Alto California, United States of America, Department of Genetics, Stanford University, Palo Alto California, United States of America

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