About the Authors

Yuchao Li

Contributed equally to this work with: Yuchao Li, Zhike Zi

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

Affiliation Max Planck Institute for Molecular Genetics, Otto Warburg Laboratory, Berlin, Germany

Difan Deng

Roles Investigation, Methodology

Affiliation German Federal Institute for Risk Assessment, Department of Experimental Toxicology and ZEBET, Berlin, Germany

Chris Tina Höfer

Roles Methodology, Writing – review & editing

Affiliation German Federal Institute for Risk Assessment, Department of Experimental Toxicology and ZEBET, Berlin, Germany

Jihye Kim

Roles Resources

Affiliation Department of Biological Sciences, KAIST Institute for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea

Won Do Heo

Roles Resources

Affiliation Department of Biological Sciences, KAIST Institute for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea

Quanbin Xu

Roles Resources

Affiliation Department of Biochemistry, University of Colorado Boulder, Boulder, Colorado, United States of America

Xuedong Liu

Roles Funding acquisition, Resources, Writing – review & editing

Affiliation Department of Biochemistry, University of Colorado Boulder, Boulder, Colorado, United States of America

Zhike Zi

Contributed equally to this work with: Yuchao Li, Zhike Zi

Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Visualization, Writing – original draft, Writing – review & editing

zk.zi@siat.ac.cn

Affiliations Max Planck Institute for Molecular Genetics, Otto Warburg Laboratory, Berlin, Germany, German Federal Institute for Risk Assessment, Department of Experimental Toxicology and ZEBET, Berlin, Germany, Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China

Competing Interests

I have read the journal’s policy and the authors of this manuscript have the following competing interests: X.L. is a cofounder of OnKure Therapeutics, Inc and Vesicle Therapeutics, Inc and owns equity in both companies. None of these companies has relationships or competing interests to this study. All other authors declare that they have no conflict of interests.