Incorporating networks in a probabilistic graphical model to find drivers for complex human diseases

Aziz M. Mezlini; Anna Goldenberg

doi:10.1371/journal.pcbi.1005580

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Open Access

Peer-reviewed

Research Article

Incorporating networks in a probabilistic graphical model to find drivers for complex human diseases

Aziz M. Mezlini,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Department of Computer Science, University of Toronto, Toronto, Ontario, Canada, Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada

http://orcid.org/0000-0002-8533-6843

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Anna Goldenberg

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: anna.goldenberg@utoronto.ca

Affiliations Department of Computer Science, University of Toronto, Toronto, Ontario, Canada, Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada

http://orcid.org/0000-0002-2416-833X

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Incorporating networks in a probabilistic graphical model to find drivers for complex human diseases

Aziz M. Mezlini,
Anna Goldenberg

Published: October 12, 2017
https://doi.org/10.1371/journal.pcbi.1005580

About the Authors

Aziz M. Mezlini

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Department of Computer Science, University of Toronto, Toronto, Ontario, Canada, Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada

http://orcid.org/0000-0002-8533-6843

Anna Goldenberg

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: anna.goldenberg@utoronto.ca

Affiliations Department of Computer Science, University of Toronto, Toronto, Ontario, Canada, Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada

http://orcid.org/0000-0002-2416-833X

Competing Interests

The authors have declared that no competing interests exist.

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Genetic networks
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Protein interaction networks
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Cancers and neoplasms
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Ovarian cancer
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Protein-protein interactions
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Gene prediction
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Schizophrenia
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Mutation
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