Similarity in Shape Dictates Signature Intrinsic Dynamics Despite No Functional Conservation in TIM Barrel Enzymes

Sandhya P. Tiwari; Nathalie Reuter

doi:10.1371/journal.pcbi.1004834

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Open Access

Peer-reviewed

Research Article

Similarity in Shape Dictates Signature Intrinsic Dynamics Despite No Functional Conservation in TIM Barrel Enzymes

Sandhya P. Tiwari,

Affiliations Department of Molecular Biology, University of Bergen, Pb. 7803, Bergen, Norway, Computational Biology Unit, Department of Informatics, University of Bergen, Pb. 7803, Bergen, Norway
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Nathalie Reuter

* E-mail: Nathalie.Reuter@mbi.uib.no

Affiliations Department of Molecular Biology, University of Bergen, Pb. 7803, Bergen, Norway, Computational Biology Unit, Department of Informatics, University of Bergen, Pb. 7803, Bergen, Norway
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Similarity in Shape Dictates Signature Intrinsic Dynamics Despite No Functional Conservation in TIM Barrel Enzymes

Sandhya P. Tiwari,
Nathalie Reuter

Published: March 25, 2016
https://doi.org/10.1371/journal.pcbi.1004834

About the Authors

Sandhya P. Tiwari

Affiliations Department of Molecular Biology, University of Bergen, Pb. 7803, Bergen, Norway, Computational Biology Unit, Department of Informatics, University of Bergen, Pb. 7803, Bergen, Norway

Nathalie Reuter

* E-mail: Nathalie.Reuter@mbi.uib.no

Affiliations Department of Molecular Biology, University of Bergen, Pb. 7803, Bergen, Norway, Computational Biology Unit, Department of Informatics, University of Bergen, Pb. 7803, Bergen, Norway

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SPT NR. Performed the experiments: SPT. Analyzed the data: SPT NR. Wrote the paper: SPT NR.

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Enzyme structure
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Protein structure comparison
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Protein structure
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Sequence alignment
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Multiple alignment calculation
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Deformation
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Protein folding
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Enzymes
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