About the Authors

Steven W. Paugh

Contributed equally to this work with: Steven W. Paugh, David R. Coss, Ju Bao, Lucas T. Laudermilk

Affiliations Hematological Malignancies Program, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America, Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

David R. Coss

Contributed equally to this work with: Steven W. Paugh, David R. Coss, Ju Bao, Lucas T. Laudermilk

Affiliation High Performance Computing Facility, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

Ju Bao

Contributed equally to this work with: Steven W. Paugh, David R. Coss, Ju Bao, Lucas T. Laudermilk

Affiliations Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America, Department of Structural Biology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

Lucas T. Laudermilk

Contributed equally to this work with: Steven W. Paugh, David R. Coss, Ju Bao, Lucas T. Laudermilk

Affiliations Hematological Malignancies Program, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America, Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

Christy R. Grace

Affiliation Department of Structural Biology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

Antonio M. Ferreira

Affiliation High Performance Computing Facility, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

M. Brett Waddell

Affiliation Molecular Interaction Analysis Laboratory, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

Granger Ridout

Affiliation Functional Genomics Laboratory, Hartwell Center for Bioinformatics & Biotechnology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

Deanna Naeve

Affiliation Functional Genomics Laboratory, Hartwell Center for Bioinformatics & Biotechnology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

Michael Leuze

Affiliation Computer Science and Mathematics Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, United States of America

Philip F. LoCascio

Affiliation Doctoral Training Centre, University of Oxford, Oxford, United Kingdom

John C. Panetta

Affiliation Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

Mark R. Wilkinson

Affiliations Hematological Malignancies Program, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America, Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

Ching-Hon Pui

Affiliations Hematological Malignancies Program, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America, Department of Oncology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

Clayton W. Naeve

Affiliation Department of Information Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

Edward C. Uberbacher

Affiliation Computer Science and Mathematics Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, United States of America

Erik J. Bonten

Affiliations Hematological Malignancies Program, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America, Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

William E. Evans

william.evans@stjude.org

Affiliations Hematological Malignancies Program, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America, Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SWP DRC JB LTL CRG AMF MBW GR DN ML PFL JCP MRW CHP CWN ECU EJB WEE. Performed the experiments: SWP DRC JB LTL CRG AMF MBW GR DN ML PFL JCP MRW EJB. Analyzed the data: SWP DRC JB LTL CRG AMF MBW GR DN ML PFL JCP MRW CHP CWN ECU EJB WEE. Contributed reagents/materials/analysis tools: SWP DRC JB LTL CRG AMF MBW GR DN ML PFL JCP MRW CHP CWN ECU EJB WEE. Wrote the paper: SWP DRC JB LTL CRG AMF MBW GR DN ML PFL JCP MRW CHP CWN ECU EJB WEE.