About the Authors

Robin van der Lee

robin.vanderlee@radboudumc.nl (RvdL); martijn.huijnen@radboudumc.nl (MAH)

Affiliation Centre for Molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands

Qian Feng

Contributed equally to this work with: Qian Feng, Martijn A. Langereis

Current address: Institute of Biochemistry, ETH Zurich, Zurich, Switzerland

Affiliation Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, University of Utrecht, Utrecht, The Netherlands

Martijn A. Langereis

Contributed equally to this work with: Qian Feng, Martijn A. Langereis

Affiliation Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, University of Utrecht, Utrecht, The Netherlands

Rob ter Horst

Affiliation Centre for Molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands

Radek Szklarczyk

Current address: Department of Clinical Genetics, Unit Clinical Genomics, Maastricht University Medical Centre, Maastricht, The Netherlands

Affiliation Centre for Molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands

Mihai G. Netea

Affiliation Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud university medical center, Nijmegen, The Netherlands

Arno C. Andeweg

Affiliation Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands

Frank J. M. van Kuppeveld

Affiliation Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, University of Utrecht, Utrecht, The Netherlands

Martijn A. Huynen

robin.vanderlee@radboudumc.nl (RvdL); martijn.huijnen@radboudumc.nl (MAH)

Affiliation Centre for Molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RvdL QF MAL MGN ACA FJvK MAH. Performed the experiments: RvdL QF MAL RtH. Analyzed the data: RvdL. Contributed reagents/materials/analysis tools: RS. Wrote the paper: RvdL QF MAL FJMvK MAH. Designed the study, analyzed the data, and wrote the manuscript: RvdL MAH. Planned and performed the large majority of (computational) analyses, data mining, data analysis, and manuscript preparation: RvdL. Designed, performed and interpreted the RNAi screening experiments, wrote the corresponding part of the manuscript and helped prepare the rest of the manuscript: QF MAL FJMvK. Calculated viral miRNA targeting scores and contributed to the integration approach: RtH. Calculated RLR co-expression and contributed to the integration approach: RS. Contributed to study design: MGN. Contributed the gene expression data and helped design the study: ACA. Supervised the study: MAH.