About the Authors

Ignacio J. General

Affiliation Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Ying Liu

Affiliation Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Mandy E. Blackburn

Affiliation Department of Biochemistry & Molecular Biology, University of Massachusetts Amherst, Amherst, Massachusetts, United States of America

Wenzhi Mao

Affiliations Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Pharmacology, Tsinghua University, Beijing, China

Lila M. Gierasch

Affiliations Department of Biochemistry & Molecular Biology, University of Massachusetts Amherst, Amherst, Massachusetts, United States of America, Department of Chemistry, University of Massachusetts Amherst, Amherst, Massachusetts, United States of America

Ivet Bahar

bahar@pitt.edu

Affiliation Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LMG IB. Performed the experiments: IJG YL MEB WM. Analyzed the data: IJG YL MEB WM LMG IB. Contributed reagents/materials/analysis tools: LMG IJG WM IB. Wrote the paper: IJG MEB LMG IB.