Within-Host Bacterial Diversity Hinders Accurate Reconstruction of Transmission Networks from Genomic Distance Data

Colin J. Worby; Marc Lipsitch; William P. Hanage

doi:10.1371/journal.pcbi.1003549

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Open Access

Peer-reviewed

Research Article

Within-Host Bacterial Diversity Hinders Accurate Reconstruction of Transmission Networks from Genomic Distance Data

Colin J. Worby ,

* E-mail: cworby@hsph.harvard.edu

Affiliation Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America
⨯
Marc Lipsitch,

Affiliation Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America
⨯
William P. Hanage

Affiliation Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America
⨯

Within-Host Bacterial Diversity Hinders Accurate Reconstruction of Transmission Networks from Genomic Distance Data

Colin J. Worby,
Marc Lipsitch,
William P. Hanage

Published: March 27, 2014
https://doi.org/10.1371/journal.pcbi.1003549

About the Authors

Colin J. Worby

* E-mail: cworby@hsph.harvard.edu

Affiliation Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America

Marc Lipsitch

Affiliation Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America

William P. Hanage

Affiliation Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CJW ML WPH. Performed the experiments: CJW. Analyzed the data: CJW. Contributed reagents/materials/analysis tools: CJW ML WPH. Wrote the paper: CJW ML WPH.

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Network analysis
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Genetics
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Species diversity
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Bacterial pathogens
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Population genetics
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Bacterial genomics
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Entropy
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Phylogenetic analysis
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