About the Authors
- Esa Pitkänen
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* E-mail: esa.pitkanen@helsinki.fi
Affiliations Department of Computer Science, University of Helsinki, Helsinki, Finland, Department of Medical Genetics, Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland
- Paula Jouhten
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Affiliation VTT Technical Research Centre of Finland, Espoo, Finland
- Jian Hou
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Affiliations Department of Computer Science, University of Helsinki, Helsinki, Finland, Department of Information and Computer Science, Aalto University, Espoo, Finland
- Muhammad Fahad Syed
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Affiliation VTT Technical Research Centre of Finland, Espoo, Finland
- Peter Blomberg
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Affiliation VTT Technical Research Centre of Finland, Espoo, Finland
- Jana Kludas
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Affiliation Department of Information and Computer Science, Aalto University, Espoo, Finland
- Merja Oja
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Affiliation VTT Technical Research Centre of Finland, Espoo, Finland
- Liisa Holm
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Affiliation Institute of Biotechnology & Department of Biosciences, University of Helsinki, Helsinki, Finland
- Merja Penttilä
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Affiliation VTT Technical Research Centre of Finland, Espoo, Finland
- Juho Rousu
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Affiliation Department of Information and Computer Science, Aalto University, Espoo, Finland
- Mikko Arvas
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Affiliation VTT Technical Research Centre of Finland, Espoo, Finland
Competing Interests
The authors have declared that no competing interests exist.
Author Contributions
Conceived and designed the experiments: EP JR MA. Performed the experiments: EP PJ JH MA. Analyzed the data: EP PJ JH JR MA. Wrote the paper: EP PJ JH MFS PB JK MO LH MP JR MA. Conceived the original method idea: EP JR. Implemented the method: EP JH MFS JK MO. Manual model curation, biomass and media definitions: EP PJ. Reaction direction constraints: EP PJ PB.