About the Authors

Tom C Freeman

To whom correspondence should be addressed. E-mail: tfreeman@staffmail.ed.ac.uk (TCF); aje@sanger.ac.uk (AJE)

Affiliations Division of Pathway Medicine, University of Edinburgh Medical School, Edinburgh, United Kingdom , Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

Leon Goldovsky

¤ Current address: Computational Biology Unit, Center for Research and Technology Hellas, Thessaloniki, Greece

Affiliation European Bioinformatics Institute, Hinxton, Cambridge, United Kingdom

Markus Brosch

Affiliation Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

Stijn van Dongen

Affiliation Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

Pierre Mazière

Affiliation Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

Russell J Grocock

Affiliation Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

Shiri Freilich

¤ Current address: Computational Biology Unit, Center for Research and Technology Hellas, Thessaloniki, Greece

Affiliation European Bioinformatics Institute, Hinxton, Cambridge, United Kingdom

Janet Thornton

Affiliation European Bioinformatics Institute, Hinxton, Cambridge, United Kingdom

Anton J Enright

To whom correspondence should be addressed. E-mail: tfreeman@staffmail.ed.ac.uk (TCF); aje@sanger.ac.uk (AJE)

Affiliation Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

TCF and AJE conceived and designed the experiments and wrote the paper. TCF, LG, SvD, and AJE performed the experiments. All authors analyzed the data. TCF, LG, MB, SvD, SF, JT, and AJE contributed reagents/materials/analysis tools.