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09/12/2018

Research Article

Selective ion permeation involves complexation with carboxylates and lysine in a model human sodium channel

Here Flood et al. use multi-microsecond atomistic simulations to observe and contrast the permeation mechanisms of sodium and potassium ions in model human and bacterial sodium channels. These channels exhibit shared features of conduction, centered on the involvement of charged protein groups that form complexes with the smaller sodium ion.

Image credit: Flood et al.

Selective ion permeation involves complexation with carboxylates and lysine in a model human sodium channel

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Current Issue August 2018

09/11/2018

Research Article

A Markov chain for numerical chromosomal instability in clonally expanding populations

Chromosomal instability (CIN) has been shown to play a key role in drug resistance and tumor metastasis. While our understanding of CIN on the cellular level has grown over the past decade, our ability to predict the behavior of tumors containing billions of cells remains limited due to the lack of adequate mathematical models. Elizalde et al. develop a Markov-chain model that is capable of providing exact solutions for long-term chromosome copy number distributions during tumor growth.

Image credit: Elizalde et al.

A Markov chain for numerical chromosomal instability in clonally expanding populations

09/10/2018

Research Article

Implications of alternative routes to APC/C inhibition by the mitotic checkpoint complex

In this manuscript, Gross et al. use a mathematical approach to explore the properties of plausible mitotic checkpoint networks. They find that seemingly similar circuits show very different behaviors for high levels of the protein targeted by the mitotic checkpoint, Cdc20. Interestingly, this protein is often overexpressed in cancer cells. For physiological levels of Cdc20, instead, all the models they have analyzed are capable to mount an efficient response.

Image credit: Gross et al.

Implications of alternative routes to APC/C inhibition by the mitotic checkpoint complex

09/13/2018

Research Article

Informational structures: A dynamical system approach for integrated information

In this paper Esteban et al. introduce a space-time continuous version for the level of integrated information of a network on which a dynamics is defined. The concept of integrated information comes from the IIT of consciousness. By a strict mathematical formulation, we complement the existing IIT theoretical framework from a dynamical systems perspective.

Informational structures: A dynamical system approach for integrated information

Image credit: Esteban et al.

09/07/2018

Research Article

Co-evolution networks of HIV/HCV are modular with direct association to structure and function

By introducing a new robust statistical method, Quadeer et al. demonstrate that the compensatory networks employed by HIV and HVC exhibit a remarkably simple decomposition involving small and near-distinct groups of protein residues, with most groups having a clear association to biological function or structure. This provides insights that can be harnessed for the purpose of vaccine design.

Co-evolution networks of HIV/HCV are modular with direct association to structure and function

Image credit: Quadeer et al.

09/06/2018

Research Article

A fully autonomous terrestrial bat-like acoustic robot

Eliakim et al. present the ‘Robat’—a fully autonomous bat-like terrestrial robot that relies on echolocation to move through a novel environment while mapping it solely based on sound. Using the echoes reflected from the environment, the Robat delineates the borders of objects it encounters, and classifies them using an artificial neural-network, thus creating a rich map of its environment.

A fully autonomous terrestrial bat-like acoustic robot

Image credit: Eliakim et al.

09/13/2018

Featured Channel

Disease Forecasting & Surveillance

This Channel includes research and online commentary related to new methods, findings, or datasets in the fields of disease forecasting and electronic disease surveillance, focusing on work with relevance to public health policy.

Disease Forecasting & Surveillance

Image credit: Martin Grandjean

05/31/2012

Featured Issue Image

Stem cells in small intestinal crypts

Fluorescently stained wholemount of mouse small intestine. A single confocal optical section at the base of the crypts is stained to show nuclei (blue), F-actin (red), and intestinal stem cells (green).

Stem cells in small intestinal crypts

Image credit: Paul Appleton, College of Life Sciences, University of Dundee.

08/29/2018

Featured Blog Post

Transparency, credit, and peer review


All of the PLOS journals join over 100 other publications to sign a joint letter committing to offering transparent peer review options.

Transparency, credit, and peer review

Image credit: PLOS

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