Selective ion permeation involves complexation with carboxylates and lysine in a model human sodium channel
Here Flood et al. use multi-microsecond atomistic simulations to observe and contrast the permeation mechanisms of sodium and potassium ions in model human and bacterial sodium channels. These channels exhibit shared features of conduction, centered on the involvement of charged protein groups that form complexes with the smaller sodium ion.
Image credit: Flood et al.