Advertisement
The intrinsic dimension of protein sequence evolution

April 8, 2019

The intrinsic dimension of protein sequence evolution

Image credit: Facco et al, pcbi.1006767.

04/08/2019

Software Article

Recentrifuge: Robust comparative analysis and contamination removal for metagenomics

Challenges in the analysis of metagenomic data include comparative study of samples, the degree of uncertainty in the results, and removal of contamination. Recentrifuge combines statistical, mathematical and computational methods to tackle those challenges: it removes diverse contamination, provides a confidence level for every result, and unveils the generalities and specificities in the samples.

Image credit: Jose Manuel Martí, pcbi.1006967.

Recentrifuge: Robust comparative analysis and contamination removal for metagenomics

Recently Published Articles

Current Issue

Current Issue March 2019

04/08/2019

Research Article

Dynamic filopodial forces induce accumulation, damage, and plastic remodeling of 3D extracellular matrices

Malandrino et al. demonstrate, through a computational and experimental study, that cell-generated dynamic local forces rapidly and mechanically remodel the extracellular matrix, creating a non-homogeneous, densified region around the cell. This substantially increases ECM protein concentration in the vicinity of cells and alters matrix mechanical properties over time, creating a new microenvironment.

Image credit: Malandrino et al, pcbi.1006684.

Dynamic filopodial forces induce accumulation, damage, and plastic remodeling of 3D extracellular matrices

04/11/2019

Editorial

Ten simple rules towards healthier research labs

The negative effects of extremely competitive academic and research environments on the performance and health of researchers are well known and common worldwide. The prevalence of these effects, particularly among early career researchers, calls for a more humane and people-centered way of working within research labs. Here, Maestre introduces 10 simple rules to make the working environment of research labs more nurturing, collaborative, and people-centered.

Image credit: PLOS.

Ten simple rules towards healthier research labs

04/09/2019

Research Article

Confidence resets reveal hierarchical adaptive learning in humans

Here, Heilbron et al. provide a direct way to test experimentally whether or not learners use a hierarchical learning strategy. Their results show that humans revise their beliefs and the confidence they hold in their beliefs in a way that is only compatible with hierarchical inference.

Confidence resets reveal hierarchical adaptive learning in humans

Image credit: Heilbron et al, pcbi.1006972.

03/18/2019

Featured Channel

Complexity

Featuring research from PLOS Computational Biology and PLOS ONE, this Channel brings together all aspects of complexity research and includes interdisciplinary topics from network theory to applications in neuroscience and the social sciences.

Complexity

Image credit: Andy Lamb.

03/29/2012

Featured Collection

Topic Pages

This Collection aims to increase the coverage of computational biology-related topics in Wikipedia by rewarding authors with a citable, PubMed-indexed static version of the living document on Wikipedia.

Topic Pages

Image credit: Monika Fischer, Flickr.

Get new content from PLOS Computational Biology in your inbox

Thank you! You have successfully subscribed to the PLOS Computational Biology newsletter.

Sorry, an error occurred while sending your subscription. Please try again later.

Try again