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April 2017

This study by Smith et al. uses genetic, environmental, and morphological data from hundreds of bird species occurring in the Western Hemisphere to evaluate patterns of within-species diversity. The authors find greater (and longer lasting) intraspecific genetic variation in tropical species than in temperate species, suggesting that biodiversity gradients can arise more rapidly than previously thought and that the processes governing these gradients operate on multiple evolutionary timescales. The image shows a close-up of a Round-tailed Manakin (Ceratopipra chloromeros), which occurs in the tropics of South America and was one of the 210 New World bird species included in the study.

Image Credit: Ben Winger

Perspectives

Should biomedical research be like Airbnb?

Vivien R. Bonazzi, Philip E. Bourne

The credibility crisis in research: Can economics tools help?

Thomas Gall, John P. A. Ioannidis, Zacharias Maniadis

Community Pages

Gut Check: The evolution of an educational board game

David A. Coil, Cassandra L. Ettinger, Jonathan A. Eisen

The School Malaise Trap Program: Coupling educational outreach with scientific discovery

Dirk Steinke, Vanessa Breton, Emily Berzitis, Paul D. N. Hebert

Research Articles

A latitudinal phylogeographic diversity gradient in birds

Brian Tilston Smith, Glenn F. Seeholzer, Michael G. Harvey, Andrés M. Cuervo, Robb T. Brumfield

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Accurate predictions of population-level changes in sequence and structural properties of HIV-1 Env using a volatility-controlled diffusion model

Orlando DeLeon, Hagit Hodis, Yunxia O’Malley, Jacklyn Johnson, Hamid Salimi, Yinjie Zhai, Elizabeth Winter, Claire Remec, Noah Eichelberger, Brandon Van Cleave, Ramya Puliadi, Robert D. Harrington, Jack T. Stapleton, Hillel Haim

Multidrug-resistant bacteria compensate for the epistasis between resistances

Jorge Moura de Sousa, Roberto Balbontín, Paulo Durão, Isabel Gordo

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Sequence learning modulates neural responses and oscillatory coupling in human and monkey auditory cortex

Yukiko Kikuchi, Adam Attaheri, Benjamin Wilson, Ariane E. Rhone, Kirill V. Nourski, Phillip E. Gander, Christopher K. Kovach, Hiroto Kawasaki, Timothy D. Griffiths, Matthew A. Howard III, Christopher I. Petkov

Water diffusion closely reveals neural activity status in rat brain loci affected by anesthesia

Yoshifumi Abe, Tomokazu Tsurugizawa, Denis Le Bihan

A novel mechanism of cone photoreceptor adaptation

Marcus H. C. Howlett, Robert G. Smith, Maarten Kamermans

Molecular regionalization of the developing amphioxus neural tube challenges major partitions of the vertebrate brain

Beatriz Albuixech-Crespo, Laura López-Blanch, Demian Burguera, Ignacio Maeso, Luisa Sánchez-Arrones, Juan Antonio Moreno-Bravo, Ildiko Somorjai, Juan Pascual-Anaya, Eduardo Puelles, Paola Bovolenta, Jordi Garcia-Fernàndez, Luis Puelles, Manuel Irimia, José Luis Ferran

Commensal bacteria and essential amino acids control food choice behavior and reproduction

Ricardo Leitão-Gonçalves, Zita Carvalho-Santos, Ana Patrícia Francisco, Gabriela Tondolo Fioreze, Margarida Anjos, Célia Baltazar, Ana Paula Elias, Pavel M. Itskov, Matthew D. W. Piper, Carlos Ribeiro

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Bordetella bronchiseptica exploits the complex life cycle of Dictyostelium discoideum as an amplifying transmission vector

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Transcriptional regulatory logic of the diurnal cycle in the mouse liver

Jonathan Aryeh Sobel, Irina Krier, Teemu Andersin, Sunil Raghav, Donatella Canella, Federica Gilardi, Alexandra Styliani Kalantzi, Guillaume Rey, Benjamin Weger, Frédéric Gachon, Matteo Dal Peraro, Nouria Hernandez, Ueli Schibler, Bart Deplancke, Felix Naef, CycliX consortium

A Ca2+ channel differentially regulates Clathrin-mediated and activity-dependent bulk endocytosis

Chi-Kuang Yao, Yu-Tzu Liu, I-Chi Lee, You-Tung Wang, Ping-Yen Wu

eNOS S-nitrosylates β-actin on Cys374 and regulates PKC-θ at the immune synapse by impairing actin binding to profilin-1

Almudena García-Ortiz, Noa B. Martín-Cofreces, Sales Ibiza, Ángel Ortega, Alicia Izquierdo-Álvarez, Antonio Trullo, Víctor M. Victor, Enrique Calvo, Begoña Sot, Antonio Martínez-Ruiz, Jesús Vázquez, Francisco Sánchez-Madrid, Juan M. Serrador

The mismatch repair and meiotic recombination endonuclease Mlh1-Mlh3 is activated by polymer formation and can cleave DNA substrates in trans

Carol M. Manhart, Xiaodan Ni, Martin A. White, Joaquin Ortega, Jennifer A. Surtees, Eric Alani

Research Matters

Less fear, more diversity

Gregory J. Quirk