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December 2015

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ELF5 Drives Lethality in Breast Cancer
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A study by David Gallego-Ortega, Christopher Ormandy and colleagues shows that up-regulation of the transcription factor ELF5 in tumors helps to create a micro-environment that recruits the innate immune system and increases vascular permeability, leading to increased metastasis in luminal breast cancer. Together with its role in anti-estrogen resistance, this suggests that ELF5 is a major driver of a lethal phenotype. The image shows metastasis nodules in the dissected lungs of a mouse model of mammary cancer that is overexpressing ELF5. The green fluorescence (EGFP) identifies the ELF5-expressing mammary cancer cells.

Image Credit: David Gallego-Ortega and Anita Ledger

Synopses

Odors Help Fruit Flies Escape Parasitoid Wasps

Robin Meadows

PLOS Biology: published December 16, 2015 | https://doi.org/10.1371/journal.pbio.1002317

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PLOS Biology: published December 22, 2015 | https://doi.org/10.1371/journal.pbio.1002327

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Essays

The Hologenome Concept: Helpful or Hollow?

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PLOS Biology: published December 4, 2015 | https://doi.org/10.1371/journal.pbio.1002311

Exceptional Antibodies Produced by Successive Immunizations

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PLOS Biology: published December 7, 2015 | https://doi.org/10.1371/journal.pbio.1002321

Unsolved Mystery

Lateral Inhibition in the Vertebrate Retina: The Case of the Missing Neurotransmitter

Richard H. Kramer, Christopher M. Davenport

PLOS Biology: published December 10, 2015 | https://doi.org/10.1371/journal.pbio.1002322

Perspective

Controlled Access under Review: Improving the Governance of Genomic Data Access

Mahsa Shabani, Stephanie O. M. Dyke, Yann Joly, Pascal Borry

PLOS Biology: published December 31, 2015 | https://doi.org/10.1371/journal.pbio.1002339

Primer

Mesocosms Reveal Ecological Surprises from Climate Change

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PLOS Biology: published December 17, 2015 | https://doi.org/10.1371/journal.pbio.1002323

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Community Page

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Research Articles

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Bidirectional Regulation of Innate and Learned Behaviors That Rely on Frequency Discrimination by Cortical Inhibitory Neurons

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Bromodomain Proteins Contribute to Maintenance of Bloodstream Form Stage Identity in the African Trypanosome

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The Constrained Maximal Expression Level Owing to Haploidy Shapes Gene Content on the Mammalian X Chromosome

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Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis

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Phosphorylation of the Synaptonemal Complex Protein Zip1 Regulates the Crossover/Noncrossover Decision during Yeast Meiosis

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