Table of Contents

October 2013

PLZF expression (in red) sustains neural progenitor proliferation and regulates the onset of Neurog2 expression (in blue) and formation of Lhx1/5+ interneurons (in green) in a chick embryo central spinal cord section. See Gaber et al. (e1001676) for more details.

Image Credit: Zachary Gaber and Bennett Novitch


Research Articles

Biotic and Human Vulnerability to Projected Changes in Ocean Biogeochemistry over the 21st Century

Camilo Mora, Chih-Lin Wei, Audrey Rollo, Teresa Amaro, Amy R. Baco, David Billett, Laurent Bopp, Qi Chen, Mark Collier, Roberto Danovaro, Andrew J. Gooday, Benjamin M. Grupe, Paul R. Halloran, Jeroen Ingels, Daniel O. B. Jones, Lisa A. Levin, Hideyuki Nakano, Karl Norling, Eva Ramirez-Llodra, Michael Rex, Henry A. Ruhl, Craig R. Smith, Andrew K. Sweetman, Andrew R. Thurber, Jerry F. Tjiputra, Paolo Usseglio, Les Watling, Tongwen Wu, Moriaki Yasuhara

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Tobin D. Northfield, Anthony R. Ives

Fitness Trade-offs Restrict the Evolution of Resistance to Amphotericin B

Benjamin Matteson Vincent, Alex Kelvin Lancaster, Ruth Scherz-Shouval, Luke Whitesell, Susan Lindquist

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A Critical Role for the Hippocampus in the Valuation of Imagined Outcomes

Maël Lebreton, Maxime Bertoux, Claire Boutet, Stéphane Lehericy, Bruno Dubois, Philippe Fossati, Mathias Pessiglione

PLZF Regulates Fibroblast Growth Factor Responsiveness and Maintenance of Neural Progenitors

Zachary B. Gaber, Samantha J. Butler, Bennett G. Novitch

The Impact of Gene Expression Variation on the Robustness and Evolvability of a Developmental Gene Regulatory Network

David A. Garfield, Daniel E. Runcie, Courtney C. Babbitt, Ralph Haygood, William J. Nielsen, Gregory A. Wray

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Functional Brachyury Binding Sites Establish a Temporal Read-out of Gene Expression in the Ciona Notochord

Lavanya Katikala, Hitoshi Aihara, Yale J. Passamaneck, Stefan Gazdoiu, Diana S. José-Edwards, Jamie E. Kugler, Izumi Oda-Ishii, Janice H. Imai, Yutaka Nibu, Anna Di Gregorio

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Identification of a New Stromal Cell Type Involved in the Regulation of Inflamed B Cell Follicles

Cyrille Mionnet, Isabelle Mondor, Audrey Jorquera, Marie Loosveld, Julien Maurizio, Marie-Laure Arcangeli, Nancy H. Ruddle, Jonathan Nowak, Michel Aurrand-Lions, Hervé Luche, Marc Bajénoff

TGF-β Signalling Is Required for CD4+ T Cell Homeostasis But Dispensable for Regulatory T Cell Function

Anna Śledzińska, Saskia Hemmers, Florian Mair, Oliver Gorka, Jürgen Ruland, Lynsey Fairbairn, Anja Nissler, Werner Müller, Ari Waisman, Burkhard Becher, Thorsten Buch

NECAP 1 Regulates AP-2 Interactions to Control Vesicle Size, Number, and Cargo During Clathrin-Mediated Endocytosis

Brigitte Ritter, Sebastian Murphy, Hatem Dokainish, Martine Girard, Manasa V. Gudheti, Guennadi Kozlov, Marilene Halin, Jacynthe Philie, Erik M. Jorgensen, Kalle Gehring, Peter S. McPherson

Structure of UreG/UreF/UreH Complex Reveals How Urease Accessory Proteins Facilitate Maturation of Helicobacter pylori Urease

Yu Hang Fong, Ho Chun Wong, Man Hon Yuen, Pak Ho Lau, Yu Wai Chen, Kam-Bo Wong

Deciphering the Structural Basis of Eukaryotic Protein Kinase Regulation

Hiruy S. Meharena, Philip Chang, Malik M. Keshwani, Krishnadev Oruganty, Aishwarya K. Nene, Natarajan Kannan, Susan S. Taylor, Alexandr P. Kornev

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Design Principles of the Yeast G1/S Switch

Xiaojing Yang, Kai-Yeung Lau, Volkan Sevim, Chao Tang

Book Review%2FScience in the Media

Seeing an Unseen Science

Karl S. Matlin