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Table of Contents

March 2006

Cover

Centriole pair integrity during mitosis.
Issue Image

A human mammary epithelial cell stained to visualize the microtubule spindles (α-tubulin), centrioles (centrin 2), and chromosomes (DAPI). The image is represented by four different color combinations, modified using Photoshop software. Splitting of centriole pairs in primary cells leads to multipolar spindles and causes mis-segregation of chromosomes during mitosis (aneuploidy). See McDermott et al.

Image Credit: Image by Kimberly M. McDermott

Editorial

Being Positive about Selection

Catriona MacCallum, Emma Hill

PLOS Biology: published March 14, 2006 | https://doi.org/10.1371/journal.pbio.0040087

Primer

The Year of the Mammoth

Alan Cooper

PLOS Biology: published February 7, 2006 | https://doi.org/10.1371/journal.pbio.0040078

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Community Page

Plant Virus Biodiversity and Ecology

Jonathan D Wren, Marilyn J Roossinck, Richard S Nelson, Kay Scheets, Michael W Palmer, Ulrich Melcher

PLOS Biology: published March 14, 2006 | https://doi.org/10.1371/journal.pbio.0040080

Research Articles

Reconstructing an Ancestral Mammalian Immune Supercomplex from a Marsupial Major Histocompatibility Complex

Katherine Belov, Janine E Deakin, Anthony T Papenfuss, Michelle L Baker, Sandra D Melman, Hannah V Siddle, Nicolas Gouin, David L Goode, Tobias J Sargeant, Mark D Robinson, Matthew J Wakefield, Shaun Mahony, Joseph G. R Cross, Panayiotis V Benos, Paul B Samollow, Terence P Speed, Jennifer A. Marshall Graves, Robert D Miller

PLOS Biology: published January 31, 2006 | https://doi.org/10.1371/journal.pbio.0040046

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  1. Marsupial Genome Sheds Light on the Evolution of Immunity

A New Description of Cellular Quiescence

Hilary A Coller, Liyun Sang, James M Roberts

PLOS Biology: published March 7, 2006 | https://doi.org/10.1371/journal.pbio.0040083

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  1. Quiet Time: Gene Program Prevents Division but Keeps Cells at the Ready

p16INK4a Prevents Centrosome Dysfunction and Genomic Instability in Primary Cells

Kimberly M McDermott, Jianmin Zhang, Charles R Holst, B. Krystyna Kozakiewicz, Veena Singla, Thea D Tlsty

PLOS Biology: published February 14, 2006 | https://doi.org/10.1371/journal.pbio.0040051

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  1. A Key Tumor Suppressor Protein Ensures Proper Chromosome Segregation during Cell Division

Gene Losses during Human Origins

Xiaoxia Wang, Wendy E Grus, Jianzhi Zhang

PLOS Biology: published February 14, 2006 | https://doi.org/10.1371/journal.pbio.0040052

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  1. When Less Is More: Losing Genes on the Path to Becoming Human

Insect Detection of Small Targets Moving in Visual Clutter

Karin Nordström, Paul D Barnett, David C O'Carroll

PLOS Biology: published February 7, 2006 | https://doi.org/10.1371/journal.pbio.0040054

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Visual Clutter Causes High-Magnitude Errors

Stefano Baldassi, Nicola Megna, David C Burr

PLOS Biology: published February 28, 2006 | https://doi.org/10.1371/journal.pbio.0040056

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Removing the Threat of Diclofenac to Critically Endangered Asian Vultures

Gerry Swan, Vinasan Naidoo, Richard Cuthbert, Rhys E Green, Deborah J Pain, Devendra Swarup, Vibhu Prakash, Mark Taggart, Lizette Bekker, Devojit Das, Jörg Diekmann, Maria Diekmann, Elmarié Killian, Andy Meharg, Ramesh Chandra Patra, Mohini Saini, Kerri Wolter

PLOS Biology: published January 31, 2006 | https://doi.org/10.1371/journal.pbio.0040066

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Complete Mitochondrial Genome and Phylogeny of Pleistocene MammothMammuthus primigenius

Evgeny I Rogaev, Yuri K Moliaka, Boris A Malyarchuk, Fyodor A Kondrashov, Miroslava V Derenko, Ilya Chumakov, Anastasia P Grigorenko

PLOS Biology: published February 7, 2006 | https://doi.org/10.1371/journal.pbio.0040073

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  1. Reading the Evolutionary History of the Woolly Mammoth in Its Mitochondrial Genome
  2. The Year of the Mammoth

A Stress Surveillance System Based on Calcium and Nitric Oxide in Marine Diatoms

Assaf Vardi, Fabio Formiggini, Raffaella Casotti, Alessandra De Martino, François Ribalet, Antonio Miralto, Chris Bowler

PLOS Biology: published February 21, 2006 | https://doi.org/10.1371/journal.pbio.0040060

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The Nicotinic Acetylcholine Receptor Dα7 Is Required for an Escape Behavior inDrosophila

Amir Fayyazuddin, Mahira A Zaheer, P. Robin Hiesinger, Hugo J Bellen

PLOS Biology: published February 28, 2006 | https://doi.org/10.1371/journal.pbio.0040063

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Glutamine-Expanded Ataxin-7 Alters TFTC/STAGA Recruitment and Chromatin Structure Leading to Photoreceptor Dysfunction

Dominique Helmlinger, Sara Hardy, Gretta Abou-Sleymane, Adrien Eberlin, Aaron B Bowman, Anne Gansmüller, Serge Picaud, Huda Y Zoghbi, Yvon Trottier, Làszlò Tora, Didier Devys

PLOS Biology: published February 28, 2006 | https://doi.org/10.1371/journal.pbio.0040067

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A Map of Recent Positive Selection in the Human Genome

Benjamin F Voight, Sridhar Kudaravalli, Xiaoquan Wen, Jonathan K Pritchard

PLOS Biology: published March 7, 2006 | https://doi.org/10.1371/journal.pbio.0040072

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  2. Clues to Our Past: Mining the Human Genome for Signs of Recent Selection
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The Cutaneous Rabbit Illusion Affects Human Primary Sensory Cortex Somatotopically

Felix Blankenburg, Christian C Ruff, Ralf Deichmann, Geraint Rees, Jon Driver

PLOS Biology: published February 28, 2006 | https://doi.org/10.1371/journal.pbio.0040069

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Correspondence and Other Communications

Neuromedin U and Its Putative Drosophila Homolog hugin

Christoph Melcher, Rüdiger Bader, Steffen Walther, Oleg Simakov, Michael J Pankratz

PLOS Biology: published March 14, 2006 | https://doi.org/10.1371/journal.pbio.0040068

Book Review%2FScience in the Media

Toward a Climate of Scientific Integrity

Beth A Fischer, Michael J Zigmond

PLOS Biology: published March 14, 2006 | https://doi.org/10.1371/journal.pbio.0040084