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Open Access

Peer-reviewed

Research Article

The murine meninges acquire lymphoid tissue properties and harbour autoreactive B cells during chronic Trypanosoma brucei infection

  • Juan F. Quintana ,

    Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

    juan.quintana@glasgow.ac.uk

    Affiliations Lydia Becker Institute of Immunology and Inflammation, University of Manchester, United Kingdom, Division of Immunology, Immunity to Infection and Health, Manchester Academic Health Science Centre, University of Manchester, United Kingdom, School of Biodiversity, One Health, Veterinary Medicine (SBOHVM), College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow United Kingdom

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  • Matthew C. Sinton,

    Roles Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

    Affiliations Lydia Becker Institute of Immunology and Inflammation, University of Manchester, United Kingdom, Division of Cardiovascular Sciences, University of Manchester, United Kingdom

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  • Praveena Chandrasegaran,

    Roles Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

    Affiliation School of Biodiversity, One Health, Veterinary Medicine (SBOHVM), College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow United Kingdom

    ⨯
  • Lalit Kumar Dubey,

    Roles Methodology, Resources, Writing – review & editing

    Affiliation Queen Mary University of London, London, United Kingdom

    ⨯
  • John Ogunsola,

    Roles Investigation, Writing – review & editing

    Affiliation School of Biodiversity, One Health, Veterinary Medicine (SBOHVM), College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow United Kingdom

    ⨯
  • Moumen Al Samman,

    Roles Investigation, Validation

    Affiliation School of Biodiversity, One Health, Veterinary Medicine (SBOHVM), College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow United Kingdom

    ⨯
  • Michael Haley,

    Roles Investigation, Validation

    Affiliations Lydia Becker Institute of Immunology and Inflammation, University of Manchester, United Kingdom, Division of Immunology, Immunity to Infection and Health, Manchester Academic Health Science Centre, University of Manchester, United Kingdom

    ⨯
  • Gail McConnell,

    Roles Investigation

    Affiliation Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), University of Strathclyde, Glasgow, United Kingdom

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  • Nono-Raymond Kuispond Swar,

    Roles Investigation

    Affiliation Department of Parasitology, National Institute of Biomedical Research, Kinshasa, Democratic Republic of the Congo

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  • Dieudonné Mumba Ngoyi,

    Roles Resources

    Affiliation Department of Parasitology, National Institute of Biomedical Research, Kinshasa, Democratic Republic of the Congo

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  • David Bending,

    Roles Resources, Writing – review & editing

    Affiliation Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom

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  • Luis de Lecea,

    Roles Writing – review & editing

    Affiliation Stanford University School of Medicine, Stanford, California, United States of America

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  • Annette MacLeod,

    Roles Writing – review & editing

    Affiliation School of Biodiversity, One Health, Veterinary Medicine (SBOHVM), College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow United Kingdom

    ⨯
  • Neil A. Mabbott

    Roles Conceptualization, Formal analysis, Writing – review & editing

    Affiliation The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, United Kingdom

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Citation: Quintana JF, Sinton MC, Chandrasegaran P, Kumar Dubey L, Ogunsola J, Al Samman M, et al. (2023) The murine meninges acquire lymphoid tissue properties and harbour autoreactive B cells during chronic Trypanosoma brucei infection. PLoS Biol 21(11): e3002389. https://doi.org/10.1371/journal.pbio.3002389

Academic Editor: Takeshi Tsubata, Tokyo Medical and Dental University Medical Research Institute, JAPAN

Received: August 14, 2023; Accepted: October 17, 2023; Published: November 20, 2023

Copyright: © 2023 Quintana et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Data Availability: The transcriptome data generated in this study have been deposited in the Gene Expression Omnibus (GSE229436). The processed transcript count data and cell metadata generated in this study, as well as the code for analysis, are available at Zenodo (DOI: 10.5281/zenodo.7814657 and https://zenodo.org/records/10018598). Additional data and files can also be sourced via Supplementary Tables. Code availability: The processed transcript count data and cell metadata generated in this study, as well as the code for analysis, are available at Zenodo (DOI: 10.5281/zenodo.7814657 and https://zenodo.org/records/10018598).

Funding: This work was funded by a Sir Henry Wellcome postdoctoral fellowship (221640/Z/20/Z to JFQ). AML is a Wellcome Trust Senior Research fellow (209511/Z/17/Z). PC and MCS are supported by a Wellcome Trust Senior Research fellowship (209511/Z/17/Z) awarded to AML. DB is funded by an MRC fellowship MR/V009052/1 and a Lister Institute Fellowship. NAM is supported by project Institute Strategic Programme Grant funding from the BBSRC (BBS/E/D/20002174 and BB/X010937/1). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Competing interests: The authors have declared that no competing interests exist.