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PLoS Biology Issue Image | Vol. 9(11) November 2011

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Conserved reaction-coupled motions promote catalysis in enzyme cyclophilin A.

Conserved reaction-coupled motions promote catalysis in enzyme cyclophilin A. The motions of distal enzyme loops (shown as thick colored tubes) impact the cis/trans isomerization reaction through changes in enzyme-substrate interactions. Substrate is shown as cyan sticks and the multiple conformations of the loops are shown to depict the direction of motion. See Ramanathan and Agarwal (e1001193).

Image Credit: Arvind Ramanathan and Pratul K. Agarwal, Oak Ridge National Laboratory

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Conserved reaction-coupled motions promote catalysis in enzyme cyclophilin A.

Conserved reaction-coupled motions promote catalysis in enzyme cyclophilin A. The motions of distal enzyme loops (shown as thick colored tubes) impact the cis/trans isomerization reaction through changes in enzyme-substrate interactions. Substrate is shown as cyan sticks and the multiple conformations of the loops are shown to depict the direction of motion. See Ramanathan and Agarwal (e1001193).

Image Credit: Arvind Ramanathan and Pratul K. Agarwal, Oak Ridge National Laboratory

https://doi.org/10.1371/image.pbio.v09.i11.g001