Figures
Conserved reaction-coupled motions promote catalysis in enzyme cyclophilin A.
Conserved reaction-coupled motions promote catalysis in enzyme cyclophilin A. The motions of distal enzyme loops (shown as thick colored tubes) impact the cis/trans isomerization reaction through changes in enzyme-substrate interactions. Substrate is shown as cyan sticks and the multiple conformations of the loops are shown to depict the direction of motion. See Ramanathan and Agarwal (e1001193).
Image Credit: Arvind Ramanathan and Pratul K. Agarwal, Oak Ridge National Laboratory
Citation: (2011) PLoS Biology Issue Image | Vol. 9(11) November 2011. PLoS Biol 9(11): ev09.i11. https://doi.org/10.1371/image.pbio.v09.i11
Published: November 29, 2011
Copyright: © 2011 Ramanathan, Agarwal. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Conserved reaction-coupled motions promote catalysis in enzyme cyclophilin A. The motions of distal enzyme loops (shown as thick colored tubes) impact the cis/trans isomerization reaction through changes in enzyme-substrate interactions. Substrate is shown as cyan sticks and the multiple conformations of the loops are shown to depict the direction of motion. See Ramanathan and Agarwal (e1001193).
Image Credit: Arvind Ramanathan and Pratul K. Agarwal, Oak Ridge National Laboratory