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Open Access

Peer-reviewed

Research Article

Adaptation to ER Stress Is Mediated by Differential Stabilities of Pro-Survival and Pro-Apoptotic mRNAs and Proteins

  • D. Thomas Rutkowski,

    Affiliation Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, Michigan, United States of America

    ⨯
  • Stacey M Arnold,

    ¤ Current address: Johns Hopkins Medical Institute, Baltimore, Maryland, United States of America

    Affiliation Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, Michigan, United States of America

    ⨯
  • Corey N Miller,

    Affiliation Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, Michigan, United States of America

    ⨯
  • Jun Wu,

    Affiliation Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, Michigan, United States of America

    ⨯
  • Jack Li,

    Affiliation Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, Michigan, United States of America

    ⨯
  • Kathryn M Gunnison,

    Affiliation Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, Michigan, United States of America

    ⨯
  • Kazutoshi Mori,

    Affiliation Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan

    ⨯
  • Amir A. Sadighi Akha,

    Affiliation Department of Pathology, University of Michigan Medical Center, Ann Arbor, Michigan, United States of America

    ⨯
  • David Raden,

    Affiliation Department of Chemical Engineering, University of Delaware, Newark, Delaware, United States of America

    ⨯
  • Randal J Kaufman

    *To whom correspondence should be addressed. E-mail: kaufmanr@umich.edu

    Affiliations Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, Michigan, United States of America , Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, Michigan, United States of America , Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, United States of America

    ⨯

Adaptation to ER Stress Is Mediated by Differential Stabilities of Pro-Survival and Pro-Apoptotic mRNAs and Proteins

  • D. Thomas Rutkowski, 
  • Stacey M Arnold, 
  • Corey N Miller, 
  • Jun Wu, 
  • Jack Li, 
  • Kathryn M Gunnison, 
  • Kazutoshi Mori, 
  • Amir A. Sadighi Akha, 
  • David Raden, 
  • Randal J Kaufman
PLOS
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  • Published: November 7, 2006
  • https://doi.org/10.1371/journal.pbio.0040374
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