Knowledge-guided analysis of "omics" data using the KnowEnG cloud platform
Fig 6
(A) Common approaches to GSC examine the overlap (top) between a user-provided gene set (e.g., genes A, D, E) and genes in a pathway (e.g., A, D, B in pathway P1). In the (bottom) knowledge network-guided mode (algorithm DRaWR), the association between 2 gene sets is based not only on direct overlap between them but also on network-based proximity between them. (B) LUSC subtype-associated pathways found exclusively with network-guided GSC pipeline using DRaWR. (C) Pathways associated with LUSC subtypes found by standard as well as network-guided GSC pipelines. GSC, gene set characterization; LUSC, lung squamous cell carcinoma.