Tissue tropism and transmission ecology predict virulence of human RNA viruses
Final classification tree structure predicting virulence. Viruses begin at the top and are classified according to split criteria (white boxes) until reaching terminal nodes with the model’s prediction of disease severity, and the fraction of viruses following that path correctly classified is shown based on literature-assigned ratings (shaded boxes). ‘Tp: primary’ denotes primary tissue tropism, ‘Tr level’ denotes level of human-to-human transmissibility, and ‘Tp: renal’ denotes having a known renal tissue tropism. Tp, tropism; Tr, transmissibility.