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2-D Structure of the A Region of Xist RNA and Its Implication for PRC2 Association

Figure 7

Representation of experimental data on possible structure 3 of human Xist A region.

Repeat 5 is located in a short central stem-loop structure flanked by two larger stem-loop structures that each contain four repeats. Representation of the enzymatic cleavages and chemical modifications are as in Figures 2 and 3. Indication of segments in which DMS and/or CMCT modifications were identified is represented as in Figure 3. The free energies of the stem-loop structures were calculated with the M-fold software.

Figure 7

doi: https://doi.org/10.1371/journal.pbio.1000276.g007