2-D Structure of the A Region of Xist RNA and Its Implication for PRC2 Association
Repeat 5 is located in a short central stem-loop structure flanked by two larger stem-loop structures that each contain four repeats. Representation of the enzymatic cleavages and chemical modifications are as in Figures 2 and 3. Indication of segments in which DMS and/or CMCT modifications were identified is represented as in Figure 3. The free energies of the stem-loop structures were calculated with the M-fold software.