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2-D Structure of the A Region of Xist RNA and Its Implication for PRC2 Association

Figure 2

Representation of experimental data on the previously proposed 2-D structure of the Xist A region.

Each of the seven repeats as well as the eighth half repeat from the mouse A region was folded according to the previously predicted two stem-loop structure [11]. T1, T2, and V1 RNase cleavages were represented by arrows surmounted by circles, triangles, and squares, respectively. Nucleotides modified by DMS or CMCT are circled. Colours of circles and arrows indicate the yields of modifications and cleavages—red, yellow, and green for strong, medium, and low modification or cleavage, respectively. The V1 RNase cleavages and chemical modifications that cannot be explained by the two stem-loop structure models are encircled by blue lanes.

Figure 2

doi: https://doi.org/10.1371/journal.pbio.1000276.g002