Emergence of a Stable Cortical Map for Neuroprosthetic Control
(A) Schematics for manual control (MC) and brain control (BC). During MC, the animal physically performs a two-dimensional center-out task using the right upper extremity while the neural activity is recorded. Under BC, the animal performs a similar center-out task using a computer cursor under direct neural control through a decoder trained during MC. (B) Stability of putative single units across multiple days. Upper panels show a set of waveforms on day 1 versus day 19. The height and width of each box are 0.5 mV and 800 µs, respectively. (C) Stability of firing properties across time. Interspike interval (ISI) distributions are shown for days 1 and 19 for three representative units. There were no significant differences between each pair of distributions (p>0.05, Kolmogrov-Smirnov Test).